| Transcribed genes |
| Gene | Score | GO annotation |
| OGT | 44 |
BP MF CC |
| biological_process | - cellular response to retinoic acid
- positive regulation of catalytic activity
- positive regulation of granulocyte differentiation
- positive regulation of histone H3-K4 methylation
more... - positive regulation of proteolysis
- protein O-linked glycosylation
- protein homotrimerization
- response to nutrient
- signal transduction
less...
|
| | cellular_component | - MLL5-L complex
- cytoplasm
- cytosol
- nucleus
more...
|
| | molecular_function | - acetylglucosaminyltransferase activity
- enzyme activator activity
- monosaccharide binding
- peptide binding
more... - protein N-acetylglucosaminyltransferase activity
- protein binding
- transferase activity, transferring glycosyl groups
less...
|
| |
| SLC20A1 | 42 |
BP MF CC |
| | cellular_component | - integral to plasma membrane
- membrane
- plasma membrane
|
| | |
| IDI1 | 42 |
BP MF CC |
| biological_process | - cholesterol biosynthetic process
- isoprenoid biosynthetic process
- response to stilbenoid
|
| | cellular_component | - cytosol
- mitochondrion
- peroxisome
|
| | molecular_function | - hydrolase activity
- isomerase activity
- isopentenyl-diphosphate delta-isomerase activity
- metal ion binding
more...
|
| |
| IFRD1 | 40 |
BP MF CC |
| biological_process | - adult somatic muscle development
- multicellular organismal development
- muscle cell differentiation
- myoblast cell fate determination
more...
|
| | | |
| CYP1B1 | 40 |
BP MF CC |
| biological_process | - angiogenesis
- cellular aromatic compound metabolic process
- endothelial cell migration
- endothelial cell-cell adhesion
more... - estrogen metabolic process
- oxidation-reduction process
- response to organic substance
- response to toxin
- retina vasculature development in camera-type eye
- toxin metabolic process
- visual perception
- xenobiotic metabolic process
less...
|
| | cellular_component | - endoplasmic reticulum
- endoplasmic reticulum membrane
- membrane
- microsome
more...
|
| | molecular_function | - aromatase activity
- electron carrier activity
- heme binding
- metal ion binding
more... - monooxygenase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- oxygen binding
less...
|
| |
| BRCA1 | 40 |
BP MF CC |
| biological_process | - DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- DNA damage response, signal transduction resulting in induction of apoptosis
- DNA recombination
- DNA repair
more... - DNA replication
- G2/M transition DNA damage checkpoint
- androgen receptor signaling pathway
- apoptosis
- brain development
- cell cycle
- cellular response to indole-3-methanol
- centrosome cycle
- chordate embryonic development
- chromosome segregation
- dosage compensation, by inactivation of X chromosome
- double-strand break repair
- double-strand break repair via homologous recombination
- negative regulation of centriole replication
- negative regulation of fatty acid biosynthetic process
- negative regulation of histone H3-K9 methylation
- negative regulation of transcription, DNA-dependent
- positive regulation of DNA repair
- positive regulation of cell cycle arrest
- positive regulation of histone H3-K4 methylation
- positive regulation of histone H3-K9 acetylation
- positive regulation of histone H4-K16 acetylation
- positive regulation of histone H4-K20 methylation
- positive regulation of histone acetylation
- positive regulation of protein ubiquitination
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- postreplication repair
- protein K6-linked ubiquitination
- protein autoubiquitination
- protein ubiquitination
- regulation of apoptosis
- regulation of cell motility
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase III promoter
- response to DNA damage stimulus
- response to estradiol stimulus
- response to estrogen stimulus
- response to ionizing radiation
- response to lipid
- response to nutrient
- substrate adhesion-dependent cell spreading
less...
|
| | cellular_component | - BRCA1-A complex
- BRCA1-BARD1 complex
- condensed nuclear chromosome
- cytoplasm
more... - filamentous actin
- focal adhesion
- gamma-tubulin ring complex
- intracellular
- mitochondrial matrix
- nucleoplasm
- nucleus
- plasma membrane
- protein complex
- ribonucleoprotein complex
- ruffle
- ubiquitin ligase complex
less...
|
| | molecular_function | - DNA binding
- RNA binding
- androgen receptor binding
- damaged DNA binding
more... - enzyme binding
- ligase activity
- metal ion binding
- protein binding
- transcription coactivator activity
- transcription regulatory region DNA binding
- tubulin binding
- ubiquitin protein ligase binding
- ubiquitin-protein ligase activity
- zinc ion binding
less...
|
| |
| TARS | 40 |
BP MF CC |
| biological_process | - gene expression
- tRNA aminoacylation for protein translation
- threonyl-tRNA aminoacylation
- translation
more...
|
| | | |
| PCK2 | 40 |
BP MF CC |
| | cellular_component | - mitochondrial matrix
- mitochondrion
- soluble fraction
|
| | molecular_function | - GTP binding
- kinase activity
- lyase activity
- metal ion binding
more... - phosphoenolpyruvate carboxykinase (GTP) activity
- phosphoenolpyruvate carboxykinase activity
- purine nucleotide binding
less...
|
| |
| MAP2K4 | 38 |
BP MF CC |
| biological_process | - JNK cascade
- MyD88-dependent toll-like receptor signaling pathway
- MyD88-independent toll-like receptor signaling pathway
- Toll signaling pathway
more... - cellular response to mechanical stimulus
- innate immune response
- protein phosphorylation
- signal transduction
- stress-activated MAPK cascade
- toll-like receptor 1 signaling pathway
- toll-like receptor 2 signaling pathway
- toll-like receptor 3 signaling pathway
- toll-like receptor 4 signaling pathway
- toll-like receptor signaling pathway
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|
| | | |
| SMAD5 | 38 |
BP MF CC |
|
| STX5 | 38 |
BP MF CC |
| | cellular_component | - Golgi apparatus
- Golgi membrane
- SNARE complex
- endoplasmic reticulum
more... - endoplasmic reticulum-Golgi intermediate compartment membrane
- integral to membrane
- membrane
- nucleolus
- nucleus
less...
|
| | molecular_function | - SNAP receptor activity
- protein N-terminus binding
|
| |
| ATF2 | 38 |
BP MF CC |
| biological_process | - MyD88-dependent toll-like receptor signaling pathway
- MyD88-independent toll-like receptor signaling pathway
- Toll signaling pathway
- adipose tissue development
more... - fat cell differentiation
- innate immune response
- outflow tract morphogenesis
- positive regulation of transforming growth factor beta2 production
- regulation of sequence-specific DNA binding transcription factor activity
- regulation of transcription, DNA-dependent
- stress-activated MAPK cascade
- toll-like receptor 1 signaling pathway
- toll-like receptor 2 signaling pathway
- toll-like receptor 3 signaling pathway
- toll-like receptor 4 signaling pathway
- toll-like receptor signaling pathway
- transcription, DNA-dependent
less...
|
| | cellular_component | - intracellular
- membrane fraction
- nucleolus
- nucleoplasm
more... - nucleus
less...
|
| | molecular_function | - DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- metal ion binding
more... - nucleic acid binding
- protein binding
- protein dimerization activity
- sequence-specific DNA binding
- sequence-specific DNA binding transcription factor activity
- transcription coactivator activity
- zinc ion binding
less...
|
| |
| PPP1R15A | 38 |
BP MF CC |
|
| TNFRSF10B | 38 |
BP MF CC |
| biological_process | - activation of NF-kappaB-inducing kinase activity
- activation of caspase activity
- activation of pro-apoptotic gene products
- apoptosis
more... - cell surface receptor linked signaling pathway
- cellular response to mechanical stimulus
- induction of apoptosis by extracellular signals
- induction of apoptosis via death domain receptors
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of apoptosis
- signal transduction
less...
|
| | cellular_component | - integral to membrane
- plasma membrane
|
| | molecular_function | - TRAIL binding
- caspase activator activity
- protein binding
- receptor activity
more...
|
| |
| HMGCR | 38 |
BP MF CC |
| biological_process | - aging
- cholesterol biosynthetic process
- coenzyme A metabolic process
- embryo development
more... - germ cell migration
- gonad development
- isoprenoid biosynthetic process
- negative regulation of MAP kinase activity
- oxidation-reduction process
- positive regulation of skeletal muscle tissue development
- response to nutrient
- visual learning
less...
|
| | | |
| RIT1 | 38 |
BP MF CC |
| biological_process | - nerve growth factor receptor signaling pathway
- signal transduction
- small GTPase mediated signal transduction
|
| | | molecular_function | - GTP binding
- GTPase activity
- calmodulin binding
- nucleotide binding
more... - protein binding
less...
|
| |
| GARS | 38 |
BP MF CC |
|
| SARS | 38 |
BP MF CC |
| biological_process | - gene expression
- seryl-tRNA aminoacylation
- tRNA aminoacylation for protein translation
- tRNA processing
more... - translation
less...
|
| | cellular_component | - cytoplasm
- cytosol
- mitochondrion
|
| | |
| CEBPG | 36 |
BP MF CC |
| biological_process | - B cell differentiation
- enucleate erythrocyte differentiation
- immune response
- liver development
more... - mRNA metabolic process
- natural killer cell mediated cytotoxicity
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of DNA binding
- positive regulation of DNA repair
- positive regulation of interferon-gamma biosynthetic process
- positive regulation of sequence-specific DNA binding transcription factor activity
- regulation of transcription from RNA polymerase II promoter
less...
|
| | | |
| IER3 | 36 |
BP MF CC |
| biological_process | - anatomical structure morphogenesis
- anti-apoptosis
- apoptosis
|
| | cellular_component | - integral to membrane
- membrane
|
| | |
| GOLGA2 | 36 |
BP MF CC |
| | cellular_component | - Golgi apparatus
- Golgi cisterna membrane
- membrane
|
| | |
| SC4MOL | 36 |
BP MF CC |
| biological_process | - cholesterol biosynthetic process
- fatty acid biosynthetic process
- fatty acid metabolic process
- steroid metabolic process
more...
|
| | cellular_component | - endoplasmic reticulum
- endoplasmic reticulum membrane
- integral to membrane
- plasma membrane
more...
|
| | molecular_function | - C-4 methylsterol oxidase activity
- iron ion binding
- oxidoreductase activity
|
| |
| ASNS | 36 |
BP MF CC |
| biological_process | - asparagine biosynthetic process
- cellular amino acid biosynthetic process
- cellular amino acid metabolic process
- cellular nitrogen compound metabolic process
more... - cellular response to glucose starvation
- cellular response to hormone stimulus
- glutamine metabolic process
- liver development
- metabolic process
- negative regulation of apoptosis
- positive regulation of mitotic cell cycle
- response to amino acid stimulus
- response to follicle-stimulating hormone stimulus
- response to light stimulus
- response to mechanical stimulus
- response to methotrexate
- response to nutrient levels
- response to toxin
less...
|
| | | |
| ATXN2L | 36 |
BP MF CC |
|
| NFE2L2 | 36 |
BP MF CC |
| biological_process | - cellular response to oxidative stress
- endoplasmic reticulum unfolded protein response
- positive regulation of blood coagulation
- positive regulation of reactive oxygen species metabolic process
more... - positive regulation of transcription from RNA polymerase II promoter
- regulation of embryonic development
- regulation of removal of superoxide radicals
- regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
less...
|
| | cellular_component | - centrosome
- chromatin
- cytoplasm
- cytosol
more... - nucleus
- plasma membrane
less...
|
| | |
| BTG1 | 36 |
BP MF CC |
| biological_process | - cell migration
- negative regulation of cell growth
- negative regulation of cell proliferation
- positive regulation of angiogenesis
more... - positive regulation of endothelial cell differentiation
- positive regulation of myoblast differentiation
- regulation of apoptosis
- regulation of transcription, DNA-dependent
less...
|
| | | molecular_function | - enzyme binding
- kinase binding
- protein binding
- transcription cofactor activity
more...
|
| |
| AARS | 36 |
BP MF CC |
| biological_process | - alanyl-tRNA aminoacylation
- cerebellar Purkinje cell layer development
- endoplasmic reticulum unfolded protein response
- gene expression
more... - hair follicle development
- negative regulation of neuron apoptosis
- neuromuscular process controlling balance
- protein folding
- response to amino acid stimulus
- skin development
- tRNA aminoacylation
- tRNA aminoacylation for protein translation
- tRNA modification
- tRNA processing
less...
|
| | cellular_component | - cytoplasm
- cytosol
- soluble fraction
|
| | molecular_function | - ATP binding
- alanine-tRNA ligase activity
- amino acid binding
- aminoacyl-tRNA editing activity
more... - ligase activity
- ligase activity, forming aminoacyl-tRNA and related compounds
- metal ion binding
- nucleic acid binding
- nucleotide binding
- tRNA binding
less...
|
| |
| FOXO3 | 36 |
BP MF CC |
| biological_process | - DNA damage response, signal transduction by p53 class mediator
- antral ovarian follicle growth
- apoptosis
- embryo development
more... - fibroblast growth factor receptor signaling pathway
- glucose homeostasis
- induction of apoptosis
- initiation of primordial ovarian follicle growth
- insulin receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- nerve growth factor receptor signaling pathway
- oocyte maturation
- ovulation from ovarian follicle
- pattern specification process
- phosphatidylinositol-mediated signaling
- positive regulation of erythrocyte differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- regulation of cell proliferation
- regulation of sequence-specific DNA binding transcription factor activity
- response to DNA damage stimulus
- tissue development
- transcription, DNA-dependent
less...
|
| | | molecular_function | - DNA bending activity
- double-stranded DNA binding
- protein binding
- protein kinase binding
more... - sequence-specific DNA binding
- sequence-specific DNA binding transcription factor activity
- sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
- transcription factor binding
less...
|
| |
| HMGCS1 | 36 |
BP MF CC |
| biological_process | - brain development
- cellular response to cholesterol
- cellular response to follicle-stimulating hormone stimulus
- cellular response to organic cyclic compound
more... - cholesterol biosynthetic process
- isoprenoid biosynthetic process
- lipid metabolic process
- liver development
- male gonad development
- response to acid
- response to drug
- response to gonadotropin stimulus
- response to lipoprotein stimulus
- response to low light intensity stimulus
- response to organic nitrogen
- response to purine-containing compound
- response to tellurium ion
- response to vitamin E
less...
|
| | cellular_component | - cytoplasm
- cytosol
- soluble fraction
|
| | |
| LPIN1 | 36 |
BP MF CC |
| biological_process | - actin cytoskeleton reorganization
- cellular lipid metabolic process
- cellular response to insulin stimulus
- fatty acid catabolic process
more... - lipid metabolic process
- mitochondrial fission
- negative regulation of transcription from RNA polymerase II promoter
- organ regeneration
- positive regulation of histone deacetylation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of fat cell differentiation
- regulation of transcription, DNA-dependent
- ruffle organization
- triglyceride biosynthetic process
- triglyceride mobilization
less...
|
| | | molecular_function | - RNA polymerase II transcription factor binding
- histone deacetylase binding
- hydrolase activity
- molecular_function
more... - peroxisome proliferator activated receptor binding
- phosphatidate phosphatase activity
- transcription coactivator activity
less...
|
| |
| N4BP2L2 | 34 |
BP MF CC |
|
| CARS | 34 |
BP MF CC |
| biological_process | - cysteinyl-tRNA aminoacylation
- gene expression
- tRNA aminoacylation for protein translation
|
| | | |
| RAB5A | 34 |
BP MF CC |
| biological_process | - GTP catabolic process
- blood coagulation
- cell differentiation
- endocytosis
more... - nervous system development
- positive regulation of exocytosis
- protein transport
- receptor internalization involved in canonical Wnt receptor signaling pathway
- regulation of filopodium assembly
- small GTPase mediated signal transduction
less...
|
| | | |
| PRIM1 | 34 |
BP MF CC |
| biological_process | - DNA replication
- DNA replication, synthesis of RNA primer
- DNA strand elongation involved in DNA replication
- DNA-dependent DNA replication initiation
more... - G1/S transition of mitotic cell cycle
- M/G1 transition of mitotic cell cycle
- S phase of mitotic cell cycle
- mitotic cell cycle
- telomere maintenance
- telomere maintenance via recombination
- telomere maintenance via semi-conservative replication
less...
|
| | cellular_component | - alpha DNA polymerase:primase complex
- nucleoplasm
|
| | molecular_function | - DNA primase activity
- metal ion binding
- nucleotidyltransferase activity
- transferase activity
more...
|
| |
| PMAIP1 | 34 |
BP MF CC |
| biological_process | - T cell homeostasis
- activation of caspase activity
- activation of pro-apoptotic gene products
- apoptosis
more... - cellular component disassembly involved in apoptosis
- cellular response to glucose starvation
- cellular response to hypoxia
- induction of apoptosis
- induction of apoptosis by intracellular signals
- negative regulation of fibroblast proliferation
- negative regulation of mitochondrial membrane potential
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- positive regulation of apoptosis
- positive regulation of caspase activity
- positive regulation of glucose metabolic process
- positive regulation of neuron apoptosis
- positive regulation of protein oligomerization
- positive regulation of release of cytochrome c from mitochondria
- proteasomal protein catabolic process
- protein insertion into mitochondrial membrane involved in induction of apoptosis
- reactive oxygen species metabolic process
- regulation of mitochondrial membrane permeability
- response to DNA damage stimulus
- response to UV
- response to X-ray
- response to dsRNA
- signal transduction by p53 class mediator resulting in induction of apoptosis
- virus-infected cell apoptosis
less...
|
| | cellular_component | - cytosol
- mitochondrial outer membrane
- mitochondrion
- nucleus
more...
|
| | |
| FUS | 34 |
BP MF CC |
| biological_process | - RNA splicing
- cell death
- gene expression
- nuclear mRNA splicing, via spliceosome
more...
|
| | cellular_component | - cytoplasm
- intracellular
- nucleolus
- nucleoplasm
more... - nucleus
less...
|
| | |
| HBP1 | 34 |
BP MF CC |
| biological_process | - Wnt receptor signaling pathway
- cell cycle arrest
- regulation of transcription, DNA-dependent
|
| | | |
| CDC6 | 34 |
BP MF CC |
| biological_process | - DNA replication
- DNA replication checkpoint
- G1/S transition of mitotic cell cycle
- M/G1 transition of mitotic cell cycle
more... - S phase of mitotic cell cycle
- cell cycle checkpoint
- cell division
- mitosis
- mitotic cell cycle
- negative regulation of DNA replication
- negative regulation of cell proliferation
- positive regulation of cell cycle cytokinesis
- positive regulation of chromosome segregation
- regulation of cyclin-dependent protein kinase activity
- regulation of mitotic anaphase
- regulation of transcription involved in G1/S phase of mitotic cell cycle
- traversing start control point of mitotic cell cycle
less...
|
| | | |
| IRS1 | 34 |
BP MF CC |
| biological_process | - cellular response to insulin stimulus
- fibroblast growth factor receptor signaling pathway
- glucose homeostasis
- insulin receptor signaling pathway
more... - insulin-like growth factor receptor signaling pathway
- lipid catabolic process
- mammary gland development
- negative regulation of insulin receptor signaling pathway
- negative regulation of insulin secretion
- negative regulation of somatostatin secretion
- nerve growth factor receptor signaling pathway
- phosphatidylinositol 3-kinase cascade
- phosphatidylinositol-mediated signaling
- positive regulation of cell migration
- positive regulation of cell proliferation
- positive regulation of fatty acid beta-oxidation
- positive regulation of glucagon secretion
- positive regulation of glucose import
- positive regulation of glucose metabolic process
- positive regulation of glycogen biosynthetic process
- positive regulation of insulin receptor signaling pathway
- positive regulation of mesenchymal cell proliferation
- positive regulation of phosphatidylinositol 3-kinase activity
- positive regulation of phosphorylation
- protein heterooligomerization
- protein localization to nucleus
- regulation of gene expression
- response to insulin stimulus
- response to peptide hormone stimulus
- signal transduction
- transmembrane receptor protein tyrosine kinase signaling pathway
less...
|
| | | molecular_function | - SH2 domain binding
- insulin receptor binding
- insulin-like growth factor receptor binding
- insulin-like growth factor-activated receptor activity
more... - phosphatidylinositol 3-kinase binding
- phosphatidylinositol-4,5-bisphosphate 3-kinase activity
- protein binding
- protein kinase C binding
- signal transducer activity
- transmembrane receptor protein tyrosine kinase adaptor activity
less...
|
| |
| USP9X | 32 |
BP MF CC |
| biological_process | - BMP signaling pathway
- cell cycle
- cell division
- chromosome segregation
more... - female gamete generation
- mitosis
- protein deubiquitination
- transforming growth factor beta receptor signaling pathway
- ubiquitin-dependent protein catabolic process
less...
|
| | | |
| HYOU1 | 32 |
BP MF CC |
| biological_process | - response to hypoxia
- response to stress
|
| | cellular_component | - endoplasmic reticulum
- endoplasmic reticulum lumen
|
| | molecular_function | - ATP binding
- nucleotide binding
|
| |
| KLF6 | 32 |
BP MF CC |
| biological_process | - B cell differentiation
- cytokine-mediated signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
more... - regulation of transcription, DNA-dependent
- wound healing
less...
|
| | cellular_component | - cytoplasm
- intracellular
- nucleus
|
| | |
| PTPN4 | 32 |
BP MF CC |
| biological_process | - protein dephosphorylation
|
| | cellular_component | - cytoplasm
- cytoskeleton
- internal side of plasma membrane
- plasma membrane
more...
|
| | |
| ATF3 | 32 |
BP MF CC |
| biological_process | - gluconeogenesis
- negative regulation of transcription, DNA-dependent
- positive regulation of cell proliferation
- regulation of transcription, DNA-dependent
more... - transcription, DNA-dependent
less...
|
| | cellular_component | - nucleolus
- nucleoplasm
- nucleus
|
| | |
| GOT1 | 32 |
BP MF CC |
| biological_process | - 2-oxoglutarate metabolic process
- L-methionine salvage from methylthioadenosine
- aspartate catabolic process
- aspartate metabolic process
more... - biosynthetic process
- carbohydrate metabolic process
- cellular amino acid biosynthetic process
- cellular amino acid metabolic process
- cellular nitrogen compound metabolic process
- cellular response to insulin stimulus
- gluconeogenesis
- glucose metabolic process
- glutamate metabolic process
- polyamine metabolic process
- response to glucocorticoid stimulus
less...
|
| | cellular_component | - axon terminus
- cytoplasm
- cytosol
- lysosome
more... - soluble fraction
less...
|
| | molecular_function | - L-aspartate:2-oxoglutarate aminotransferase activity
- L-phenylalanine:2-oxoglutarate aminotransferase activity
- carboxylic acid binding
- pyridoxal phosphate binding
more... - transaminase activity
less...
|
| |
| HSPA5 | 32 |
BP MF CC |
| biological_process | - ATP catabolic process
- ER overload response
- ER-associated protein catabolic process
- activation of signaling protein activity involved in unfolded protein response
more... - anti-apoptosis
- blood coagulation
- cellular response to glucose starvation
- cerebellar Purkinje cell layer development
- cerebellum structural organization
- endoplasmic reticulum unfolded protein response
- negative regulation of apoptosis
- negative regulation of caspase activity
- negative regulation of transforming growth factor beta receptor signaling pathway
- platelet activation
- platelet degranulation
- positive regulation of protein ubiquitination
- proteolysis involved in cellular protein catabolic process
- regulation of protein folding in endoplasmic reticulum
less...
|
| | cellular_component | - caspase complex
- cell surface
- endoplasmic reticulum
- endoplasmic reticulum chaperone complex
more... - endoplasmic reticulum lumen
- endoplasmic reticulum membrane
- endoplasmic reticulum-Golgi intermediate compartment
- extracellular region
- integral to endoplasmic reticulum membrane
- melanosome
- midbody
- nucleus
- perinuclear region of cytoplasm
- signalosome
less...
|
| | molecular_function | - ATP binding
- ATPase activity
- calcium ion binding
- caspase inhibitor activity
more... - chaperone binding
- misfolded protein binding
- nucleotide binding
- protein binding
- protein binding, bridging
- protein domain specific binding
- ribosome binding
- ubiquitin protein ligase binding
- unfolded protein binding
less...
|
| |
| CITED2 | 32 |
BP MF CC |
| biological_process | - adrenal cortex formation
- adrenal gland development
- anti-apoptosis
- blood vessel development
more... - cell proliferation
- central nervous system development
- decidualization
- determination of left/right symmetry
- embryonic placenta development
- embryonic process involved in female pregnancy
- heart development
- liver development
- multicellular organismal development
- negative regulation of cell migration
- negative regulation of gene expression
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- positive regulation of cell cycle
- positive regulation of cell-cell adhesion
- positive regulation of gene expression
- positive regulation of male gonad development
- positive regulation of peroxisome proliferator activated receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- positive regulation of transforming growth factor beta receptor signaling pathway
- regulation of organ formation
- regulation of transcription, DNA-dependent
- response to estrogen stimulus
- response to fluid shear stress
- response to hypoxia
- sex determination
- transcription, DNA-dependent
- trophectodermal cell differentiation
- vasculogenesis
less...
|
| | cellular_component | - cytoplasm
- nuclear chromatin
- nucleus
|
| | |
| SEPHS2 | 32 |
BP MF CC |
| biological_process | - selenocysteine biosynthetic process
|
| | | molecular_function | - ATP binding
- catalytic activity
- nucleotide binding
- selenide, water dikinase activity
more... - transferase activity
less...
|
| |
| NFIL3 | 32 |
BP MF CC |
| biological_process | - circadian rhythm
- immune response
- regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
more...
|
| | | |
| GADD45A | 32 |
BP MF CC |
| biological_process | - DNA repair
- G2/M transition of mitotic cell cycle
- apoptosis
- cell cycle arrest
more... - cellular response to ionizing radiation
- cellular response to mechanical stimulus
- centrosome cycle
- negative regulation of protein kinase activity
- positive regulation of reactive oxygen species metabolic process
- regulation of cyclin-dependent protein kinase activity
- signal transduction in response to DNA damage
less...
|
| | | |
| DUSP8 | 32 |
BP MF CC |
| biological_process | - inactivation of MAPK activity
- peptidyl-tyrosine dephosphorylation
- protein dephosphorylation
|
| | | molecular_function | - MAP kinase tyrosine/serine/threonine phosphatase activity
- hydrolase activity
- protein tyrosine phosphatase activity
|
| |
| KIF2A | 32 |
BP MF CC |
| biological_process | - M phase of mitotic cell cycle
- blood coagulation
- cell differentiation
- cell division
more... - microtubule-based movement
- mitotic cell cycle
- mitotic prometaphase
- mitotic spindle organization
- multicellular organismal development
- nervous system development
less...
|
| | | molecular_function | - ATP binding
- microtubule motor activity
- motor activity
- nucleotide binding
more... - protein binding
less...
|
| |
| TAX1BP1 | 32 |
BP MF CC |
| | | molecular_function | - kinase binding
- protein binding
- zinc ion binding
|
| |
| CYP1A1 | 32 |
BP MF CC |
| biological_process | - 9-cis-retinoic acid biosynthetic process
- amine metabolic process
- camera-type eye development
- cell proliferation
more... - cellular lipid metabolic process
- coumarin metabolic process
- developmental process
- dibenzo-p-dioxin catabolic process
- digestive tract development
- drug metabolic process
- embryo development ending in birth or egg hatching
- flavonoid metabolic process
- hepatocyte differentiation
- hydrogen peroxide biosynthetic process
- insecticide metabolic process
- maternal process involved in parturition
- oxidation-reduction process
- porphyrin-containing compound metabolic process
- positive regulation of S phase of mitotic cell cycle
- response to antibiotic
- response to arsenic-containing substance
- response to drug
- response to food
- response to herbicide
- response to hyperoxia
- response to hypoxia
- response to iron(III) ion
- response to lipopolysaccharide
- response to nematode
- response to organic cyclic compound
- response to virus
- response to vitamin A
- response to wounding
- vitamin D metabolic process
- xenobiotic metabolic process
less...
|
| | cellular_component | - cytoplasm
- endoplasmic reticulum
- endoplasmic reticulum membrane
- membrane
more... - microsome
- mitochondrion
less...
|
| | molecular_function | - aromatase activity
- demethylase activity
- electron carrier activity
- enzyme binding
more... - flavonoid 3'-monooxygenase activity
- heme binding
- metal ion binding
- oxidoreductase activity
- oxidoreductase activity, acting on diphenols and related substances as donors
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- oxygen binding
- steroid hydroxylase activity
- vitamin D 24-hydroxylase activity
less...
|
| |
| SMG1 | 32 |
BP MF CC |
| biological_process | - DNA repair
- RNA metabolic process
- mRNA export from nucleus
- mRNA metabolic process
more... - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- peptidyl-serine phosphorylation
- phosphatidylinositol phosphorylation
- protein autophosphorylation
- response to stress
less...
|
| | | |
| CREBBP | 30 |
BP MF CC |
| biological_process | - N-terminal peptidyl-lysine acetylation
- cell proliferation
- cellular lipid metabolic process
- gene expression
more... - histone acetylation
- homeostatic process
- innate immune response
- interspecies interaction between organisms
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- protein complex assembly
- regulation of S phase
- regulation of transcription, DNA-dependent
- response to hypoxia
- signal transduction
- transcription, DNA-dependent
less...
|
| | cellular_component | - cytoplasm
- histone acetyltransferase complex
- nuclear body
- nucleoplasm
more... - nucleus
less...
|
| | molecular_function | - MyoD binding
- SMAD binding
- acetyltransferase activity
- histone acetyltransferase activity
more... - metal ion binding
- p53 binding
- peroxisome proliferator activated receptor binding
- protein binding
- sequence-specific DNA binding transcription factor activity
- signal transducer activity
- transcription coactivator activity
- transcription factor binding
- transferase activity
- zinc ion binding
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|
| |
| ZC3H15 | 30 |
BP MF CC |
| biological_process | - cytokine-mediated signaling pathway
|
| | cellular_component | - cytoplasm
- nucleolus
- nucleus
- plasma membrane
more...
|
| | molecular_function | - metal ion binding
- nucleic acid binding
- zinc ion binding
|
| |
| NRAS | 30 |
BP MF CC |
| biological_process | - MAPKKK cascade
- Ras protein signal transduction
- actin cytoskeleton organization
- activation of MAPKK activity
more... - axon guidance
- blood coagulation
- epidermal growth factor receptor signaling pathway
- insulin receptor signaling pathway
- leukocyte migration
- nerve growth factor receptor signaling pathway
- positive regulation of Rac protein signal transduction
- positive regulation of cell proliferation
- regulation of long-term neuronal synaptic plasticity
- regulation of synaptic transmission, GABAergic
- signal transduction
- small GTPase mediated signal transduction
- striated muscle cell differentiation
- visual learning
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|
| | cellular_component | - Golgi apparatus
- Golgi membrane
- membrane fraction
- plasma membrane
more...
|
| | molecular_function | - GTP binding
- GTPase activity
- Ral guanyl-nucleotide exchange factor activity
- nucleotide binding
more...
|
| |
| MTCH2 | 30 |
BP MF CC |
| | cellular_component | - integral to membrane
- membrane
- mitochondrial inner membrane
- mitochondrion
more...
|
| | |
| ANGEL2 | 30 |
BP MF CC |
|
| PPA1 | 30 |
BP MF CC |
| biological_process | - diphosphate metabolic process
- gene expression
- phosphate-containing compound metabolic process
- tRNA aminoacylation for protein translation
more...
|
| | | molecular_function | - hydrolase activity
- inorganic diphosphatase activity
- magnesium ion binding
|
| |
| N4BP1 | 30 |
BP MF CC |
| biological_process | - negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of protein ubiquitination
|
| | | |
| SNRPC | 30 |
BP MF CC |
| biological_process | - nuclear mRNA splicing, via spliceosome
- spliceosomal snRNP assembly
|
| | cellular_component | - Cajal body
- U1 snRNP
- nucleus
- ribonucleoprotein complex
more...
|
| | |
| NDUFA9 | 30 |
BP MF CC |
| | | molecular_function | - 3-beta-hydroxy-delta5-steroid dehydrogenase activity
- NADH dehydrogenase (ubiquinone) activity
- NADH dehydrogenase activity
- binding
more... - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
less...
|
| |
| ACAT2 | 30 |
BP MF CC |
| | cellular_component | - cytoplasm
- mitochondrion
- nucleolus
- nucleus
more...
|
| | molecular_function | - acetyl-CoA C-acetyltransferase activity
- transferase activity
- transferase activity, transferring acyl groups other than amino-acyl groups
|
| |
| ENSA | 30 |
BP MF CC |
|
| RAB8A | 30 |
BP MF CC |
| | | molecular_function | - GTP binding
- nucleotide binding
- protein binding
|
| |
| ATF4 | 30 |
BP MF CC |
| biological_process | - cellular amino acid metabolic process
- gluconeogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
more... - regulation of transcription, DNA-dependent
- response to endoplasmic reticulum stress
- transcription from RNA polymerase II promoter
- transcription, DNA-dependent
less...
|
| | | |
| TSN | 30 |
BP MF CC |
| | | molecular_function | - DNA binding
- mRNA binding
- sequence-specific DNA binding
|
| |
| AIMP1 | 30 |
BP MF CC |
| biological_process | - angiogenesis
- apoptosis
- carbohydrate metabolic process
- cell adhesion
more... - cell-cell signaling
- chemotaxis
- gene expression
- glucose metabolic process
- inflammatory response
- leukocyte migration
- negative regulation of endothelial cell proliferation
- response to wounding
- signal transduction
- tRNA aminoacylation for protein translation
less...
|
| | | molecular_function | - cell surface binding
- cytokine activity
- protein homodimerization activity
- tRNA binding
more...
|
| |
| BCAP29 | 30 |
BP MF CC |
| biological_process | - apoptosis
- intracellular protein transport
- vesicle-mediated transport
|
| | cellular_component | - endoplasmic reticulum
- endoplasmic reticulum membrane
- integral to membrane
- membrane
more...
|
| | |
| TDRD3 | 30 |
BP MF CC |
| | | molecular_function | - chromatin binding
- methylated histone residue binding
- nucleic acid binding
- transcription coactivator activity
more...
|
| |
| NCSTN | 30 |
BP MF CC |
| biological_process | - Notch receptor processing
- Notch signaling pathway
- amyloid precursor protein catabolic process
- apoptosis
more... - induction of apoptosis by extracellular signals
- membrane protein ectodomain proteolysis
- membrane protein intracellular domain proteolysis
- nerve growth factor receptor signaling pathway
- positive regulation of catalytic activity
- protein processing
- proteolysis
less...
|
| | | molecular_function | - aspartic-type endopeptidase activity
- endopeptidase activity
- peptidase activity
- protein binding
more...
|
| |
| TBCB | 30 |
BP MF CC |
| | cellular_component | - cytoplasm
- microtubule
- microtubule cytoskeleton
|
| | |
| SUCLG2 | 30 |
BP MF CC |
| biological_process | - succinyl-CoA metabolic process
- tricarboxylic acid cycle
|
| | cellular_component | - mitochondrial matrix
- mitochondrion
|
| | |
| RREB1 | 30 |
BP MF CC |
| | cellular_component | - cytoplasm
- intracellular
- nuclear body
- nuclear speck
more... - nucleus
less...
|
| | molecular_function | - DNA binding
- metal ion binding
- nucleic acid binding
- zinc ion binding
more...
|
| |
| VAV3 | 30 |
BP MF CC |
| biological_process | - B cell receptor signaling pathway
- angiogenesis
- apoptosis
- blood coagulation
more... - cell migration
- induction of apoptosis by extracellular signals
- integrin-mediated signaling pathway
- intracellular signal transduction
- lamellipodium assembly
- nerve growth factor receptor signaling pathway
- platelet activation
- positive regulation of B cell proliferation
- positive regulation of GTPase activity
- positive regulation of cell adhesion
- positive regulation of phosphatidylinositol 3-kinase activity
- regulation of GTPase activity
- regulation of Rho protein signal transduction
- regulation of small GTPase mediated signal transduction
- response to DNA damage stimulus
- response to drug
- small GTPase mediated signal transduction
- vesicle fusion
less...
|
| | cellular_component | - cytoplasm
- cytosol
- plasma membrane
|
| | molecular_function | - GTPase activator activity
- Rac guanyl-nucleotide exchange factor activity
- Rho guanyl-nucleotide exchange factor activity
- SH3/SH2 adaptor activity
more... - epidermal growth factor receptor binding
- guanyl-nucleotide exchange factor activity
- metal ion binding
- protein binding
less...
|
| |
| DCTN6 | 30 |
BP MF CC |
| | cellular_component | - centrosome
- cytoplasm
- cytoskeleton
- dynactin complex
more...
|
| | molecular_function | - dynein binding
- transferase activity
|
| |
| SLC39A7 | 30 |
BP MF CC |
| biological_process | - ion transport
- transmembrane transport
- zinc ion transport
|
| | cellular_component | - endoplasmic reticulum membrane
- integral to membrane
- membrane
- membrane fraction
more...
|
| | molecular_function | - metal ion transmembrane transporter activity
|
| |
| HNRNPU | 30 |
BP MF CC |
| biological_process | - CRD-mediated mRNA stabilization
- RNA processing
- RNA splicing
- gene expression
more... - nuclear mRNA splicing, via spliceosome
less...
|
| | | |
| CES2 | 30 |
BP MF CC |
| | cellular_component | - endoplasmic reticulum
- endoplasmic reticulum lumen
|
| | |
| AKAP11 | 30 |
BP MF CC |
| biological_process | - intracellular protein kinase cascade
- regulation of protein kinase A signaling cascade
|
| | cellular_component | - cytoplasm
- cytoskeleton
- microtubule organizing center
- protein complex
more...
|
| | |
| TCEB1 | 30 |
BP MF CC |
| biological_process | - gene expression
- interspecies interaction between organisms
- positive regulation of viral transcription
- regulation of transcription from RNA polymerase II promoter
more... - transcription elongation from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
- ubiquitin-dependent protein catabolic process
- viral reproduction
less...
|
| | cellular_component | - VCB complex
- cytosol
- nucleoplasm
- nucleus
more...
|
| | |
| TCF12 | 30 |
BP MF CC |
| biological_process | - cell differentiation
- immune response
- multicellular organismal development
- muscle organ development
more... - nervous system development
- regulation of transcription from RNA polymerase II promoter
- regulation of transcription, DNA-dependent
- transcription, DNA-dependent
less...
|
| | | molecular_function | - DNA binding
- protein binding
- sequence-specific DNA binding transcription factor activity
- transcription regulatory region DNA binding
more...
|
| |
| TMEM39A | 30 |
BP MF CC |
| | cellular_component | - integral to membrane
- membrane
|
| | |
| RC3H2 | 30 |
BP MF CC |
| | | molecular_function | - DNA binding
- metal ion binding
- nucleic acid binding
- zinc ion binding
more...
|
| |
| VPS24 | 30 |
BP MF CC |
| | cellular_component | - cytoplasm
- cytosol
- early endosome
- late endosome membrane
more... - membrane
- midbody
less...
|
| | molecular_function | - phosphatidylinositol-4,5-bisphosphate binding
- protein binding
|
| |
| PRMT2 | 30 |
BP MF CC |
| biological_process | - developmental cell growth
- histone arginine methylation
- histone methylation
- induction of apoptosis
more... - negative regulation of G1/S transition of mitotic cell cycle
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of transcription, DNA-dependent
- peptidyl-arginine N-methylation
- positive regulation of transcription, DNA-dependent
- protein methylation
- regulation of androgen receptor signaling pathway
- signal transduction
less...
|
| | cellular_component | - Rb-E2F complex
- cytoplasm
- cytosol
- nucleus
more...
|
| | molecular_function | - androgen receptor binding
- estrogen receptor binding
- histone methyltransferase activity
- histone-arginine N-methyltransferase activity
more... - methyltransferase activity
- peroxisome proliferator activated receptor binding
- progesterone receptor binding
- protein binding
- protein homodimerization activity
- protein-arginine N-methyltransferase activity
- retinoic acid receptor binding
- signal transducer activity
- thyroid hormone receptor binding
- transcription coactivator activity
- transferase activity
less...
|
| |
| FAM178A | 30 |
BP MF CC |
|
| PTPLA | 30 |
BP MF CC |
| biological_process | - fatty acid biosynthetic process
- multicellular organismal development
- peptidyl-tyrosine dephosphorylation
- protein dephosphorylation
more... - signal transduction
less...
|
| | cellular_component | - endoplasmic reticulum
- endoplasmic reticulum membrane
- integral to membrane
- membrane
more...
|
| | molecular_function | - lyase activity
- protein tyrosine phosphatase activity
|
| |
| WNK1 | 30 |
BP MF CC |
| | cellular_component | - cytoplasm
- soluble fraction
- vesicular fraction
|
| | molecular_function | - ATP binding
- nucleotide binding
- protein binding
- protein kinase activity
more... - protein kinase inhibitor activity
- protein serine/threonine kinase activity
- transferase activity, transferring phosphorus-containing groups
less...
|
| |
| OBSL1 | 30 |
BP MF CC |
| biological_process | - cardiac myofibril assembly
- cytoskeleton organization
|
| | cellular_component | - M band
- Z disc
- intercalated disc
- perinuclear region of cytoplasm
more...
|
| | molecular_function | - cytoskeletal adaptor activity
|
| |
| WWTR1 | 30 |
BP MF CC |
| biological_process | - cilium morphogenesis
- glomerulus development
- hippo signaling cascade
- negative regulation of canonical Wnt receptor signaling pathway
more... - negative regulation of catenin import into nucleus
- negative regulation of fat cell differentiation
- negative regulation of protein kinase activity
- negative regulation of protein phosphorylation
- negative regulation of transcription from RNA polymerase II promoter
- osteoblast differentiation
- positive regulation of cell proliferation
- positive regulation of epithelial to mesenchymal transition
- positive regulation of transcription from RNA polymerase II promoter
- regulation of SMAD protein import into nucleus
- regulation of transcription, DNA-dependent
- stem cell division
less...
|
| | cellular_component | - cytoplasm
- nucleolus
- nucleus
- transcription factor complex
more...
|
| | molecular_function | - protein binding
- protein homodimerization activity
- transcription coactivator activity
- transcription corepressor activity
more...
|
| |
| XBP1 | 30 |
BP MF CC |
| biological_process | - endoplasmic reticulum unfolded protein response
- epithelial cell maturation involved in salivary gland development
- exocrine pancreas development
- immune response
more... - regulation of transcription, DNA-dependent
- response to drug
- response to electrical stimulus
- serotonin secretion, neurotransmission
- transcription from RNA polymerase II promoter
- transcription, DNA-dependent
less...
|
| | cellular_component | - endoplasmic reticulum membrane
- nucleoplasm
- nucleus
|
| | molecular_function | - DNA binding
- protein dimerization activity
- sequence-specific DNA binding
- sequence-specific DNA binding transcription factor activity
more...
|
| |
| EIF3E | 30 |
BP MF CC |
| | | molecular_function | - protein N-terminus binding
- protein binding
- translation initiation factor activity
|
| |
| PHB | 30 |
BP MF CC |
| biological_process | - DNA replication
- cellular response to interleukin-6
- histone deacetylation
- negative regulation of androgen receptor signaling pathway
more... - negative regulation of cell growth
- negative regulation of cell proliferation
- negative regulation of glucocorticoid receptor signaling pathway
- negative regulation of transcription by competitive promoter binding
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- progesterone receptor signaling pathway
- regulation of apoptosis
- regulation of transcription, DNA-dependent
- signal transduction
less...
|
| | | molecular_function | - histone deacetylase binding
- protein binding
- transcription regulatory region DNA binding
|
| |
| ASAH1 | 30 |
BP MF CC |
| biological_process | - ceramide metabolic process
- lipid metabolic process
|
| | | molecular_function | - catalytic activity
- ceramidase activity
- hydrolase activity
|
| |
| ITGB3BP | 30 |
BP MF CC |
| biological_process | - CenH3-containing nucleosome assembly at centromere
- M phase of mitotic cell cycle
- apoptosis
- cell adhesion
more... - induction of apoptosis by extracellular signals
- mitotic cell cycle
- mitotic prometaphase
- nerve growth factor receptor signaling pathway
- nucleosome assembly
- regulation of transcription, DNA-dependent
- signal transduction
less...
|
| | | molecular_function | - protein C-terminus binding
- signal transducer activity
|
| |
| POLR1D | 30 |
BP MF CC |
| biological_process | - termination of RNA polymerase I transcription
- transcription elongation from RNA polymerase I promoter
- transcription from RNA polymerase I promoter
- transcription initiation from RNA polymerase I promoter
more...
|
| | | molecular_function | - DNA binding
- DNA-directed RNA polymerase activity
- protein dimerization activity
|
| |
| MYST1 | 30 |
BP MF CC |
| biological_process | - chromatin modification
- histone H4-K16 acetylation
- histone acetylation
- myeloid cell differentiation
more... - negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
less...
|
| | cellular_component | - MLL1 complex
- MSL complex
- nucleus
|
| | |
